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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43bb8e211fb50bbef94b5c2ce1410ae60b61538603391bdb965865df50d4f4f0' 
  AND token = 'V04kmfW8pYwphsz/jGqsk1nb3vt1kFFAH64oA26beXk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}