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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42e49dd8b6455c9ba5df4640a67c9d253b2b0dfec94b11fa9e7002dbd544cb33' 
  AND token = 'RP+YW9yl5/7+qfujht61eEFPN0kSH32DkQCDV68gfB8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}