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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21ee45cc8303f57363f85e5faf05c30ba7b5612d8e3713cf2d87544be1a98533' 
  AND token = 'e7pDAd9gZZb5fsJ8tLcVHiKrh+QYe+nVK5UAIvaeUkA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}