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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '280e87792527fc4efc14ee3141222e368e6252b03b93d0b9789f994d5a739d2d' 
  AND token = 'w2ZBcHuk3IGnSZ0FzlTpJWfBQFdxH07dpFza7m8f04E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}